on Monday, January 14th, 2019 2:54 | by Anders Eriksson
on Wednesday, December 19th, 2018 2:52 | by Björn Brembs
We are looking for a PhD student for behavioral experiments with Drosophila fruit flies with manipulated FoxP function.
The human orthologues of the fly FoxP gene are the FOXP1-4 genes. Mutations in the FOXP2 gene cause verbal dyspraxia, a form of articulation impairment. Humans learn to articulate phonemes and words by a form of motor learning we can model in flies. Supporting the conceptual analogy of motor learning in humans and flies, manipulations of the fly FoxP gene also lead to impairments in motor learning.
In the past year, graduate student Ottavia Palazzo used CRISPR/Cas9 to edit the FoxP gene locus, tagging the gene with reporters. These reporters allow us to manipulate not only the gene, but also the neurons which express FoxP. The candidate will work closely with Ottavia to design behavioral experiments characterizing the various manipulations of the different neuronal populations for their involvement in the form of motor learning we use, operant self-learning at the torque meter:
The position is fully funded by a grant from the German funding agency DFG, with full healthcare, unemployment, etc. benefits. It includes admission and tuition to the “Regensburg International Graduate School of Life Sciences“. Starting date is as soon as convenient.
The successful candidate will have a Master’s degree or equivalent. They will be proficient in English as our group is composed of international members. The ideal candidate will have some training in behavioral experiments in Drosophila or other animals, some coding experience and an inclination towards electronics. However, all of these skills can also be learned during the project.
We are a small, international group consisting of a PI (Björn Brembs), a postdoc (Anders Eriksson), one more graduate student besides Ottavia (Christian Rohrsen) and a technician. We are an open science laboratory and so one aspect of the project will involve a new open science initiative in our laboratory, where we have developed a simple method to make our behavioral data openly accessible automatically, i.e., without any additional efforts by the experimenter. This entails at least two advantages for the candidate in addition to doing science right: the data are automatically backed up and there is no need for a data management plan.
Regensburg is a university town in Bavaria, Germany with about 120k inhabitants and a vibrant student life, due to the 20k students enrolled here. The University of Regensburg is an equal opportunity employer.
Interested candidates should contact Björn Brembs with a CV and a brief letter of motivation.
on Monday, October 1st, 2018 2:39 | by Anders Eriksson
on Tuesday, August 7th, 2018 2:49 | by Anders Eriksson
The experiment was done as a pilot experiment before doing a larger scale.
The data is a bit inconsistent but shows a positive and reassuring numerical difference. The control is a bit lower than expected, compared to WTB flies (showing usually a PI 0f 0.6). The flies have a slightly different background than wtb flies and have pale orange eyes (still no apparent impairments in vision). Further experiments will be conducted before proceeding with a larger sample size of the flies.
on Monday, July 30th, 2018 2:08 | by Amanda Torres
on Monday, July 2nd, 2018 1:55 | by Anders Eriksson
on Friday, April 29th, 2016 10:25 | by Björn Brembs
With all our undergraduate students graduating and our graduate student on research leave, the lab has now shrunk to two people plus our technician. Looks like it’s going to be lonely for a while.
on | by Björn Brembs
We are very happy with the work of these two students, we enjoyed their time with us and hope they also enjoyed their research here in our lab. All the best to you two!
on Thursday, March 24th, 2016 10:55 | by Björn Brembs
Farewell you two, we enjoyed having you in the lab and will always be happy seeing you again. Good luck and all the best!